Over the past 10 years there have been almost annual meta-analyses and systematic reviews published in numerous refereed international journals evaluating the role of immunotherapy in IVF treatment.

The treatments have included steroids e.g.prednisolone, Intravenous Immunoglobulin (IVIg), TNF-a blocking agents,and intralipid infusions.

The Practice Committee of the American Society for Reproductive Medicine (ASRM) concluded that “there is no association between anti-phosphlipid antibodies (APA) and IVF success; therefore there is no justification for assessment or treatment of APA in couples undergoing IVF.”

Uterine Natural Killer (uNK) cells were only one of a range of immune and vascular abnormalities found in the endometrium (uterine lining) of women with recurrent implantation failure.

A recent systematic review of the literature stated “This review does not support the use of prednisolone, IVIg, or any other adjuvant treatment in women who are undergoing Assisted Reproductive Technology (ART) who are found to have elevated absolute numbers or activity of uNK cells purely due to the absence of, or poor quality of, the evidence.”

Another recent meta-analysis of studies evaluating the role of uNK cells in regard to IVF outcome concluded by stating ” on the basis of current evidence, uNK analysis and immune therapy should be offered only in the context of clinical research.”

Finally, another high quality review evaluating corticosteroid therapy in ART argued ” unless overt immunne pathology is evident, utilization of corticosteroids is not warranted and may be harmful.”

Do not subject yourself to the possible serious side effects of medication that currently has no proven benefit. It will not increase your your chances of having a healthy normal baby and may make you significantly unwell.

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